anti metal toxicity
supplement facts

About CHELOREX™ and The effects of heavy metal toxicity

CHELOREX™ : A new, safe, extremely effective, convenient, and less expensive approach for removing Toxic Heavy Metal from the body ( Chelation ).

CHELOREX™  is an all natural, physician formulated oral chelation product designed specifically for chronic metal poisoning. Chronic metal poisoning (CMP) represents about 98% of all toxic metal poisoning. It differs from acute metal poisoning (AMP) in that : chronic metal poisoning occurs as a result of prolonged exposure to multiple toxic metals. It usually develops insidiously with gradual onset of symptoms, often barely noticed. AMP occurs suddenly with obvious symptoms, often due to exposure to a single toxic metal.

Chronic metal poisoning is associated with depletion of essential trace minerals and of glutathione and other antioxidants resulting in:

1) Impairment of the bodies own chemical detoxification mechanisms with associated chemical sensitivities (MCS).

2) Impaired thyroid function due to inability to convert T4 to T3.

3) Mitochondria! dysfunction and impaired oxidative phosphorylation, excessive free radical formation and the release of inflammatory cytokines. This results in fatigue, pain and inflammation, impaired immune function, susceptibility to chronic degenerative disease, accelerated aging, and less than optimal mental and physical functioning.

4) Synthetic chelation agents such as DMPS and DMSA were formulated for acute metal poisoning (AMP). While they are able to mobilize large amounts of lead, mercury and other metals, they contain no antioxidants to protect the body and have a high incidence of moderate to severe adverse side effects, especially in persons with multiple chemical sensitivities or previously existing liver or kidney damage.

Why is CHELOREX™ your best choice for oral chelation?

1) Contains no synthetic chelating agents, therefore no dangerous adverse reactions (synthetic chelation agents produce moderate to severe adverse responses in 30% of persons undergoing chelation.)

2) Enhances your body’s natural detoxification mechanisms via multiple routes.

3) Provides support for chemical detoxification by stimulating glutathione synthesis and providing selenium, magnesium and zinc.

4) Natural effective mobilization of toxic metals while avoiding toxic overload of liver and  kidneys seen with synthetic chelators.

5) Provides antioxidant protection against free radicals.

6) Marked enhancement of GI excretion with bowel protection.

7) Safe for chemically sensitive persons.

8) No EDTA avoids risk of neurotoxic complex with mercury.

9) Effective for entire spectrum of toxic metals.

10) Most cost effective of all chelators.

11) Only oral chelating agent with clinical studies showing excellent ability to reduce levels of all toxic metals in hair while markedly enhancing urinary and fecal excretion. Other oral chelation agents have no comparable studies (most have no studies at all) or have inadequate levels of chelating agents to be effective.

12) Can be used for long-term protection for persons who must sustain chronic environmental exposure.

13) Contains both water-soluble agents and lipid soluble agents, capable of penetrating the blood-brain barrier and cellular membranes.

In what ways is CHELOREX™  superior to IV chelation?

1) CHELOREX™  can be used safely at home, even in persons with amalgam fillings.

2) A 90 dose course of oral chelation with CHELOREX™  costs a small fraction of the price of IV chelation ($210-280 vs $3000-5000)

3) Because CHELOREX™  contains no synthetic chemicals, it can be used safely in chemically sensitive people.

4) Oral chelation with CHELOREX™ avoids the discomfort of IV needles and the inconvenience of going to a doctor’s office or clinic, This is especially welcome news for persons who have poor veins or are markedly overweight.

5) CHELOREX™  can be used daily and for long periods with appropriate monitoring by hair analysis.

6) CHELOREX™  has no serious adverse side effects.

7) CHELOREX™  enhances excretion by multiple pathways intestinal tract, hair, perspiration and urinary tract.

8) CHELOREX™  does not require a prescription.

9) Trace mineral depletion is minimized.

10) CHELOREX™  can be used to protect the body during amalgam replacement.

11) Multiple components of CHELOREX™  have been shown to protect mitochondrial function.

12) Oral chelation with CHELOREX™  avoids the problems of toxic redistribution of metals seen with DMPS.

13) CHELOREX™  removes the full spectrum of toxic metals.

How is CHELOREX™  superior to EDTA?

1) EDTA forms a neurotoxic complex with mercury which prevents the polymerization of tubulin in the nervous system. (REF. #1) See Duhr, et al. HgEDTA complex inhibits GTP interactions with the E site of brain beta-tubulin. Toxicol Appl Pharmacol 122(2): 273-280 (1993).

2) EDTA is a narrow spectrum chelation agent which removes primarily lead and calcium. CHELOREX™  has been shown to remove the entire spectrum of toxic metals from aluminum to uranium. This is important because the presence of multiple toxic metals significantly lowers the toxic threshold for each toxic metal present. For example, a given level of mercury will be more toxic if lead is also present and both these levels will be more toxic at a lower level if arsenic or cadmium are also present.

3) EDTA is known to be poorly absorbed from the gastro-intestinal tract, reducing its effectiveness in the oral form.

4) CHELOREX™  contains both water soluble and lipid soluble components allowing it to penetrate the blood-brain barrier and cell membrane as well as the extra-cellular space. EDTA has never been shown to penetrate the blood-brain barrier.

What is chelation therapy?

In 1974 The World Health Organization reported that “82% of all chronic disease are caused by environmental exposure to toxic metals.”

Q: Why should I be concerned with toxic metal in my body?

A: In 1974 The World Health Organization reported that “82% of all chronic degenerative diseases are caused by environmental exposure to toxic metals.” This is further substantiated by over 5,000 pages of US government funded toxicological reports found at the *ATSDR website. CHELOREX™  was developed in 2002 to help those with many health complaints to , restore health and energy by cleansing the body of toxic metals (via Chelation) and reducing their external exposure ( i.e. contaminated water, food, personal care products, toxic homes etc.) and internal exposure (i.e. amalgam fillings).

Q: Do I have Metal Toxicity

A: In my experience, over 90% of patients tested by hair analysis have at least one toxic metal over the normal reference range, particularly metal workers, mechanics, painters, printers, carpenters, plumbers, electricians, electronic technicians, jewelers and people who handle firearms, or solder.

Q: What is Chelation Therapy?

A: Chelation therapy for toxic metals is a procedure that introduces a substance (natural or synthetic) into the body which bonds to toxic metals in blood and various tissues, thus protecting the body from harmful effects. The body then excretes the bound toxic metals through the kidney, GI tract, sweat glands and hair.

Q: What is the difference in Chelation methods available?

A: The most common chelation methods are intravenous (IV) and oral. In IV chelation, the chelating agent is injected directly into the blood stream over 2-3 hr period. It is performed in an office, hospital or clinic 1-2 times per week for 3-6 months. The cost rangers from $3000-$5000. Oral chelation involves taking a chelating agent by mouth in the form of pills or liquid, prescription, or non-prescription formulas. These can be taken at home, work or while on vacation. (usual 6 to 12 week time period). Cost ranges from $150 to $2,000 depending on the agent.

Q: What is the best Chelating agent?

A: In addition to the ability to bind and remove toxic metals, an ideal chelator like CHELOREX™  can do so without producing adverse effects. Most of the prescription chelators (IV & Oral) have had a high incidence of significant adverse reactions for four reasons. 1) Synthetic chelators must be detoxified. A high portion of people with metal toxicity have impairment of glutathione dependent detoxification mechanisms and are already chemically sensitive, leading to severe side effects. 2) Synthetic chelators cause excessive toxic metal release in persons whose antioxidant defenses are depleted due to chronic metal poisoning resulting in immune suppression and free radical damage to the body. 3) EDTA has been shown to form a toxic complex with mercury which can damage the brain. (REF.#1) 4) Chelators can cause significant essential trace metal depletion.

Q: Why do you prefer the natural chelator CHELOREX™ ?

A: Synthetic chelating agents have a very high incidence of severe adverse reactions because they release excessive amounts of toxic metals in patients whose anti-oxidant defenses are depleted. In addition, studies have shown them to be relatively ineffective in reversing physical, neurological and behavioral symptoms of chronic metal poisoning. Following a course of chelation, levels of toxic metals, especially lead, tend to rebound after an initial decrease because of ongoing release of lead from bone or recurrent environmental exposure. Clearly, what was needed was an effective chelating agent for all toxic metals, based on natural therapeutic ingredients which could penetrate the blood brain barrier and be taken safely for an extended period of time at a reasonable cost with minimal or no side effects. Using my background in biochemistry and my clinical experience, I formulated a combination of individual natural ingredients that performed well on my patients without adverse side effects. Listed below are the individual ingredients and some of their functions, which have been verified by numerous studies. Using the most cost effective natural chelators available, we performed clinical studies which thus far have exceeded expectations with removal rates on 16 toxic metals over the normal reference range as high as 98% for a (90 dose / 45 day) treatment.

Q: Should I be on a chelating agent before I remove my amalgam fillings?

A: Synthetic chelators are contraindicated in this situation.. However our formulation can be safely taken in order to protect against transient surges of mercury which can occur during amalgam replacement. CHELOREX™ not only binds the mercury, but protects tissues from free radicals by raising glutathione levels, providing antioxidants, and supplying protective trace minerals (Zn, Mg, and Se).

Q: Why do you recommend hair analysis?

A: Hair analysis is the best indicator of chronic exposure and total body burden for toxic metals. It is used by government, private industry, law enforcement, and by natural health practitioners. It provides a vast amount of information regarding toxic and trace minerals which relate to health and nutrition, at a tiny fraction of the cost of other methods such as blood and urine testing which only reflect recent toxic metal exposure. It is the only practical method of assessing for multiple toxic metal exposures, which is extremely common. It also should be used to monitor the progress of chelation therapy. Significant residual levels of lead and other toxic metals indicate the need for additional chelation with CHELOREX™. This is crucial, especially where there is continuing occupational or environmental exposure.

Do I have metal toxicity?

Toxic Heavy Metal: Contamination can come from the food we eat, the water we drink, the things we touch and the air we breath on a daily basis. They accumulate in our bodies over the years or quickly through unusual extreme exposure.

Take The Test And See. Review these questions to see if Toxic Heavy Metals maybe a problem for you or a loved one .

Answering yes to at least ( 5 ) of these questions could indicate that you have at least one toxic metal over the normal reference range.

1. Are you more fatigued than you should be?

2. Do you sleep poorly or do you have frequent insomnia?

3. Do you get depressed easily, or have you taken antidepressants in the past?

4. Have you had frequent headaches or ringing in the ears?

5. Have you had bleeding or sore gums (gingivitis) frequently?

6. Have you had mental symptoms such as confusion or forgetfulness?

7. Have you had shakiness or tremors of your hands and arms or twitching of other muscles?

8. Do you often have a “metallic” taste in your mouth?

9. Have you worked as a dentist, hygienist, or dental assistant?

10. Do you have numbness or unexplained tingling in your arms or legs?

11. When seen by doctors for your health problems, are you usually told  “There is nothing wrong”?

12. Does your skin have many “brown spots” or “age spots” under your eyes or elsewhere?

13. Do you have “irritable bowel syndrome” or problems with constipation or diarrhea?

14. Do you have a lot of bad breath or white tongue (thrush)?

15. Do you get yeast infections of the mouth, vagina or intestinal tract or had Candida Related Complex (CRC)?

16. Do you suffer from hay fever, respiratory, or lack energy to do the things you need to do?

17. Do you have numbness or burning sensations in your mouth or gums?

18. Have you had frequent kidney have frequent mood swings, or do you have significant kidney problems?

19. Do you have difficulty with concentration.

20. Have you had difficulty with your balance, do you fall frequently or have difficulty standing on one foot?

21. Do you have unidentified chest pains even after EKG’S, X-ray, and heart studies are normal.

22. Have you ever worked as a : steamfitter, pipe fitter, welder, plumber, printer, miner, mechanic, metal worker, machinist, carpenter, manufacturing / chemical or pesticide / fungicide factories (fungicides with methyl mercury ingredients) or in pulp / paper mills that used mercury?

23. Do you have 6 or more “silver” fillings?

24. Do you often have a lot of mucus in your stools?

25. Do you have persistent pain in your joints?

26. Have you frequently had low basal body (axillary) temperature (below 97.8 degrees F.)?

27. Do you have heart irregularities or rapid pulse?

28. Do you have frequent skin pain or rashes?

29. Allergies or food allergies or intolerance?

30. Do you have frequent colds, flu, irritability or sudden changes in behavior?

What’s the best chelating agent?

toxic metals

DMSA and DMPS are not recommended in persons with amalgam fillings. **EDTA forms neurotoxic complex with mercury — not recommended in persons with amalgams or history of mercury exposure.

Non prescription CHELOREX™

Non prescription chelation agents: The case for safe and effective chelation .

Multiple clinical studies have shown individual non-FDA regulated food and herbal supplement ingredients have been found to be extremely effective in removing multiple toxic metals. Below is a list of the individual ingredients in the current CHELOREX™ formula, along with a brief functional summary.

Science Formulas LLC, CHELOREX™  offers a Physicians formulated combination of the below and other supportive ingredients in a single formula. Clinical study data demonstrating the formula’s effectiveness in reduction of body burden as revealed by hair analysis before and after chelation is the best evidence of efficacy. Studies demonstrating increased levels of toxic metals being excreted in urine, or stools provide only an imprecise indication of excretion, but does not provide information regarding remaining toxic metal burden.

(REF. #2) References to Scientific reviews of Ingredients listed :

Listed under each CHELOREX™  formula ingredient below is the mechanism and supporting reference.

Vitamin E:  (as d-alpha-tocopherol succinate): Antioxidant, supports thyroid function Chang, L.W, Gilbert,M and Sprecher,J: Modification of methylmercury neurotoxicity by vitamin E, Environ. Res. 1978;17:356-366

Selenium:  (as sodium selenite): Enhances chemical detoxification, reduces toxicity of metals, necessary for conversion of T4 to T3 for normal thyroid function. Selenium is an important constituent of glutathione peroxidase, which breaks down toxic peroxides and free radicals. It has been shown to significantly reduce heavy metal toxicity. Yoneda S, Suzuki KT Detoxification of mercury by selenium by binding of equimolar Hg-Se complex to a specific plasma protein. Toxicol Appl Pharmacol 1997;143(2):274-280 Johansson E: Selenium and its protection against the effects of mercury and silver. J Trace Elements 1991;5:273-274Gailer 3; George GN; Pickering IJ, et al. Structural Basis of the Antagonism between Inorganic Mercury and Selenium in Mammals. Chem Res Toxicol 2000 Nov 20;13(11):1135-1142

Vitamin C:  (as ascorbic acid): Promotes excretion of toxic metals, essential antioxidant, supports thyroid function. Vitamin C is known to enhance the excretion of toxic metals in the gut and to protect against free radical damage Hill, CH. Interactions of vitamin C with lead and mercury. Ann N Y Acad Sci 1980;355:262-6 Yamini B, Sleight SD. Effects of ascorbic acid deficiency on methyl mercury dicyandiamide toxicosis in guinea pigs 3 Environ Pathol Toxicol Oncol 1984 Jul;5(4-5):139-50 Zorn NE, Smith JT A relationship between vitamin B12, folic acid, ascorbic acid, and mercury uptake and methylation. Life Sci 1990;47(2):167-73 Iyengar GV; Nair PP. Global outlook on nutrition and the environment: meeting the challenges of the next millennium. Sci Total Environ 2000 Apr 17;249(1-3):331-46.

Zinc: (as zinc citrate): Stimulates metallothionine, reduces toxicity of metals Journal of Orthomolecular Psychiatry 7 (2):94-106 1978Flora SJ, Tandon SK: Beneficial effects of zinc supplementation during chelation treatment of lead intoxication in rats, Toxicology, 1990 Nov; 64 (2): 129 -39

Magnesium:  (as magnesium aspartate): Aids in chelation, replaces lost or chelated magnesium, protects against free radical damage. Assists in removing lead and other toxic metals. Reduces free radical damage from radiation and toxic substances. 1) Chugh SN, Kolley T, Kakkar R, Chugh K, Sharma A., A critical evaluation of anti-peroxidant effect of intravenous magnesium in acute aluminum phosphide poisoning. 2) 235: Soldatovic D, Vujanovic D, Matovic V, Plamenac Z. Compared effects of high oral Mg supplements and of EDTA chelating agent on chronic lead intoxication in rabbits. Magnes Res. 1997 Jun;10(2):127-33. PMID: 9368233, 3) 321: Soldatovic D, Matovic V, Vujanovic D. Prophylactic effect of high magnesium intake in rabbits exposed to prolonged lead intoxication. Magnes Res. 1993 Jun;6(2):145-8. PMID: 8274359

Alpha-Lipoic Acid:  Binds intracellular toxic metals, quenches free radicals and raises glutathione levels. Alpha lipoic acid is a sulfur-containing co-factor for many essential biochemical reactions with potent antioxident properties. It is lipid and water soluble and can penetrate the blood brain barrier. This helps to remove toxic metals from the CNS. Ziegler C, et al: Alpha-lipoic acid in the treatment of diabetic neuropathy in Germany: current evidence from clinical trials, Experimental & Clinical Endocrinology & Diabetes 1999;107(7):421-30.Ziegler C, et al: Alpha-lipoic acid in the treatment of diabetic neuropathy in Germany: current evidence from clinical trials, Experimental & Clinical Endocrinology & Diabetes 1999;107(7):421-30.Gregus Z, et al: Effect of lipoic acid on biliary excretion of glutathione and metals, Toxicology & Applied Pharmacology 1992 May; 114(1): 88 -96.

Taurine:  Enhances biliary excretion, protects CNS, retina, and white blood cells.

Taurine is a conditionally essential sulfur containing amino acid found in meat, fish, eggs and dairy products that appears to function as a neuromodulator and protective antioxidant in the CNS, where it is present in large amounts. Taurine levels are reduced in patients with lead poisoning. Taurine also protects the kidneys and retina from free radical damage by toxic metals and also protects the liver, heart, lungs and neutrophiles. Taurine has also been shown to enhance the secretion of toxic metals in bile. Chesney, R.W. et al: Role of taurine in infant nutrition, Adv Exp Med Biol 1998 442: 463-76. Stapleton PP et al: Host Defense – a role for the amino acid taurine? Parenter Enteral Nutr. 1998 Jan-Feb;22(1):42-8. Schuller-Levis GB, Park E: Taurine- new implications for an old amino acid. FEMS Microbiol Lett. 2003 Sep 26;226(2):195-202. Redmond HP et al. Immunonutrition – the role of taurine. Nutrition 1998 Jul-Aug; 14(7-8):599-604 Kontny E et al:The mechanism of taurine -choramine inhibition of cytokine production by rheumatoid arthritis fibroblast-like synoviocytes; Arthritis Rheum 2000 Oct,43(10):169-77.

Chlorella:  Traps toxic metals in the GI tract. Acts as an ion exchange resin. Chlorella is a species of unicellular fresh water algae that has been shown to possess detoxifying properties enabling it to assist or support the human detoxification system. Chlorella algae contain phytochemicals that support Phase I and Phase II detoxification reactions while the cell walls function as an ion exchange resin to absorb and retain toxic metals which can then be excreted. Chlorella can be used as a significant source of nutrients including vitamins, amino acids, fatty acids and minerals. They possess no toxicity and 20 grams or more can be ingested daily without any adverse effect. H.B.Xue, W.Stumm, L.Sigg: The binding of Heavy Metals to Algal Surfaces, Water Res 1988;22, 917Carr HP, et al. Characterization of the cadmium-binding capacity of Chlorella vulgaris. Bull Environ Contam Toxicol. 1998;60(3): 433-440M.Kraft: Bindungsverhalten von Arsen, Cadmium, Chrom, Quecksilber, Nickel und Blei an schwerverdauliche Lebensmittel und Lebensmittelkomponenten in kuenstlichem Magen-Darm-Saft. PhD Thesis. Institut fuer Hygiene, Sozial-und umweltmedizin der Ruhr-Universitaet Bochum, Germany, (1998)Ahner, AB, Kong KS, Morel! MM, Phytochelatin production in marine algea: An interspecies comparison. Limnol Oceanograph 1995;40: 649-657Northcote DH et al, 1958 The chemical composition and structure of the cell wall of Chlorella pyrenoidosa. .Biochem 3 70:391-97. Travieso RO et al. 1999Heavy Metal Removal by microalgae. Bull. Environ.Contam.Toxico1.62:144- 151.

Cilantro:  (aerial parts) (from 10:1 extract): Mobilizes toxic metals from the central nervous system and other tissues. Cilantro is a vegetable in the parsley family shown by Omura and others to be an effective chelator of CNS toxic metals. Its active component is a mercaptan that can penetrate the blood brain barrier. Omura Y, Beckman SL Role of mercury (Hg) in resistant infections & effective treatment of Chlamydia trachomatis and Herpes family viral infections (and potential treatment for cancer) by removing localized Hg deposits with Chinese parsley and delivering effective antibiotics using various drug uptake enhancement methods. Acupunct Electrother Res. 1995;20(3-4): 195- 2290mura Y, Shimotsuura Y, Fukuoka A, Fukuoka H, Nomoto T. Significant mercury deposits in internal organs following the removal of dental amalgam, & development of pre-cancer on the gingiva and the sides of the tongue and their represented organs as a result of inadvertent exposure to strong curing light (used to solidify synthetic dental filling material) & effective treatment: a dinical case report, along with organ representation areas for each tooth. Acupunct Electrother Res. 1996 ;21(2): 133-16098 Ewan KB, Pamphlett R Increased inorganic mercury in spinal motor neurons following chelating agents. Neurotoxicology 1996;17(2):343-349

MSM: (methylsulfonylmethane): Enhances permeability of cell membranes. Methyl sulfonyl methane or MSM is a naturally occurring sulfur containing molecule found in fruits, vegetables, seafood and meat. It is present in the body and humans excrete from 4-11 mg. daily in urine. Research suggests that it is required for the body to preserve normal function and structure. Its toxicity is about equal to water. Food processing destroys the MSM normally present in food. MSM aids in detoxifying metals by contributing sulfur to methionine and cysteine as well as peptides and proteins and is eventually incorporated into connective tissue. It is also believed to enhance detoxification by increasing the permeability of cell walls. Recommended dosage for continuous use is 3000-6000 mg/day. When starting MSM some individuals may experience transient diarrhea, headache, skin rash, or fatigue associated with the release of toxins. Jacob, Stanley W, M.D., Lawrence, Ronald M, M.D., PhD, Zucker, Martin The Miracle of MSM, The Natural Solution for Pain New York: Berkley Books 1999

L-Glutamine: Restores and preserves gastro-intestinal function, enhances hair excretion, glutathione precursor Glutamine is utilized as a source of energy and for nucleotide synthesis in all rapidly dividing cells. Hair follicles depend on it for energy production so that it assists the hair follicle in excreting toxic metals and the lining of the intestine in resisting the effects of toxic metals. It also is involved in the detoxification of ammonia, which reduces ATP production and thus ammonia interferes with detoxification reactions that depend on adequate supplies of ATP. Toxic metal poisoning frequently interferes with the regulation of glucose levels in the body, increasing susceptibility to hypoglycemia. Glutamine can prevent hypoglycemia since it is easily converted in glucose. Glutamine is a substrate for glutathione, which plays a major role in the body’s antioxidant and detoxification defenses. Both glutamine and glutathione are reduced in lead toxicity.Williams R. et al; Metabolism of freshly isolated human hair follides capable of hair elongation: a glutaminolytic aerobic glucolytic tissue; 3 Invest Dermatol. 1993 June; 100(6):834-40 Fox AD et al; Effect of a glutamine-supplemented enteral diet on methotrexate induced enterocolitis. J Parenter Enteral Nutr. 1988 Jul-Aug, 12(4):325-31 Cao Y et al ;Glutamine enhances gut glutathione production; J Parenter Enteral Nutr.1998 Jul-Aug;

22(4):224-7 Wessner B, et al; Effect of single and combined supply of glutamine, glycine, n- acetylcysteine and R,S alpha lipoic acid on glutathione content of myelomonocytic cells. Clin Nutr. 2003 Dec;22(6):515-22.

NAC:  (N-Acetylcysteine): Binds toxic metals, raises glutathione levels and acts as antioxidant. Yim CY, et al: Use of N-Acetylcysteine to increase intracellular glutathione during induction of antitumor responses by IL-2, Journal of Immunology, 1994 Jan 15; 152(12):5796-805.Meyer A, Buhl R, Magnussen H: The effect of oral N-acetylcysteine on lung glutathione levels in idiopathic pulmonary fibrosis, European Respiratory Journal, 1994 Mar; 7(3):431-

How much CHELOREX™ do I need?

For maximum results we recommend a minimum of 90 (ninety) doses, the same dosing amount used in the CHELOREX™  formula studies. Use this chart to determine the correct amount of CHELOREX™  to order  / 1 BOTTLE = 540 CAPLETS

Body Weight         Amount of Caplets           Amount of Caplets               Amount of CHELOREX™

   Per Dose                          For 90 Doses

100-105 lbs                10 Caplets                         900 Caplets                               2 Bottles

116-125 lbs                12 Caplets                       1080 Caplets                              2 Bottles

126-135 lbs.               13 Caplets.                      1170 Caplets                              3 Bottles

136-145 lbs                14 Caplets                       1260 Caplets                              3 Bottles

146-155 lbs                15 Caplets                     1350 Caplets                                3 Bottles

156-165 lbs                16 Caplets                     1440 Caplets                                3 Bottles

166-175 lbs                 17 Caplets                     1530 Caplets                               3 Bottles

176 lbs & above          18 Caplets                    1620 Caplets                                3 Bottles

CHELOREX™ 540 Caplets per Bottle

ADULT DIRECTIONS: Take with meals or food and with sufficient liquid to swallow . Do not swallow all caplets at once . Do not exceed 18 caplets per dose ; even if you weigh more than 180 lbs . Do not exceed 36 caplets daily

For CHELOREX™: Maximum Results:

Morning Dosage: 1 caplet per 10 lbs. of body weight (Up to 18 caplets)

Evening Dosage: 1 caplet per 10 lbs. of body weight (Up to 18 caplets)

Example 1: A 180 lb. (and above) person would take 18 caplet dose in the morning & a 18 caplet dose in the evening for 45 days or you may take one morning or evening dose per day for 90days

Example 2 : A 120 lb. person would take 12 caplet dose in the morning & a 12 caplet dose in the evening for 45 days or you may take one morning or evening dose per day for 90 days.

Drink: 6-8 glasses of pure water per day.

Maintenance Dosage: 2-6 caplets daily

( THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE. + )

Hair Analysis

About HAIR ANALYSIS and it’s Elemental Profiles

Since it is believed that blood toxic metal levels are correlated with acute (1 to 2 week) but not chronic toxic metal exposure, hair levels of toxic metals may give a better indication of body toxic metal burden and overall exposure. Hair analysis is extremely cost effective and also gives an indication of total toxic metal load. This is important because one frequently finds exposure to several different toxic metals which would not be apparent from a single blood test. In addition to toxic metals, hair analysis can provide valuable data regarding essential trace minerals in the body. This can be extremely helpful in pinpointing serious deficiencies or imbalances . Doctor’s Data utilizes the most up to date and accurate technology available.

More information on Hair Analysis can be found at http://www.doctorsdata.com

Our intention was to find a biomarker that would give us the best indication of overall efficacy. We believe the best to be Total Toxic Metal Body Burden. Many other chelation products have published studies showing increases of a single toxic metal such as lead or mercury in urine and blood after being challenged by the chelator tested. However , measurements of metals in urine and blood provide an indication of only transient changes in metal levels. Urinary levels are a reflection of how much metal is being cleared from blood by the kidneys during a relatively brief interval (hours). Blood levels tend to be transient and within hours are cleared from blood and either excreted or deposited in various tissues .

Neither urine nor blood levels provide an indication of other pathways of excretion or of reduction of total body load. While an increased urinary level of lead or mercury provides an indication that a single toxic metal is being excreted, it does not provide data regarding how many other toxic metals are present or how much residual metal is left post- chelation. A recent study of DMSA challenge from Emory University in Atlanta revealed no correlation between past occupational exposure to mercury and mercury excretion before or after DMSA challenge.13 Furthermore, challenge studies incur a significant risk of serious side effects (see below) and also of kidney damage, particularly in older individuals. The best method for determining total toxic metal body burden would probably be some type of MRI spectroscopy. However, MRI for toxic metals has yet to be developed.

The most reliable and cost effective method commercially available, as well as the safest, is hair analysis by a quality laboratory. Hair analysis is very well documented and referenced with respect to measuring body burden of heavy metals such as Lead, Mercury, Cadmium, and Arsenic. The World Health Organization, the International Atomic Energy Agency, and the U.S. Environmental Protection Agency CDC, NIH and Justice Dept. have all recommended hair analysis for determination of heavy metals. . The EPA stated in a report “…if hair samples are properly collected and cleaned, and analyzed by the best analytic methods, using standards and blanks as required, in a clean and reliable laboratory by experienced personnel, the data are reliable.” (USEPA 600/4-79-049).

Hair analysis provides a vast amount of information regarding toxic and trace minerals which relate to health and nutrition, at a tiny fraction of the cost of other methods such as blood and urine testing, which only reflect recent, but not chronic toxic metal exposure. Just as the measurement of glycosylated hemoglobin (HbAlc)- has been found to be a more accurate measure of average blood sugar levels than random blood glucose levels, toxic metal levels in hair provide a more accurate reflection of toxic metal accumulation in the body. Furthermore, a single hair sample provides information concerning levels of an entire spectrum of toxic metals. Hair analysis frequently reveals exposure to several different toxic metals, which would not be apparent from a single blood or urine test. Persons with suspected lead or mercury poisoning need to be tested for all toxic metals, not just lead or mercury because studies have shown that the presence of more than one heavy metal lowers the toxic threshold for each toxic metal. Since our study attempts to determine the efficacy of our formulation as a broad- spectrum chelating agent, hair analysis was the only viable choice.

The evaluation of trace mineral levels in the body is important for several reasons. 1. Low levels of essential minerals such as zinc, selenium, calcium and magnesium are believed to make persons more vulnerable to the toxic effects of heavy metals. 2. High levels of toxic metals are believed to cause depletion of essential minerals such as selenium and zinc, which in turn can have important physiological effects such as impairment of thyroid function and impairment of detoxification mechanisms for chemicals and drugs. 3. Symptoms of trace mineral depletion may be mistaken for metal poisoning or may aggravate metal poisoning.

More government published information on the viability of hair analysis can be found at: HAIR ANALYSIS PANEL DISCUSSION : EXPLORING THE STATE OF THE SCIENCE.

ATSDR

AGENCY FOR TOXIC SUBSTANCES AND DISEASE REGISTRY

http://www.atsdr.cdc.qov/HAC/hair analvsis/pdfs.html

CHELOREX™  — Testing protocol

The following is a summary of the testing protocol to which volunteers agreed .

Volunteer selection criteria : Volunteers selected had at least 1 toxic metal over the normal reference range on a hair analysis performed by Doctors Data, Inc. and agreed to follow the “Volunteers Agreement”. No other discrimination of any other type was used.

***Responsibilities of the Volunteer: Summary:

1) Pre testing (hair)

2) 45 days or 90 doses of CHELOREX™  (as per directions) (hair test at 45 days or 90 doses)

3) Post testing 30 days after 90th dose (to allow for hair sample to grow out)

Before Starting

1) Provide hair sample as per Doctors Data collection procedures. (At home or mail in)

2) Fill out pre-study general health questionnaire.

***During 45 day or 90 dose period:

1) Take CHELOREX™  twice daily for 45 days (morning & evening) as per directions or once daily for 90 days. Stop at 45 days or (90 dose equivalent)

***After 45 days or 90 dose period :

1) Provide hair sample as per Doctors Data collection procedures. (At home or mail in) at end of 45 days or (90 doses) (Very important to follow directions– only hair 1/3″ from scalp to be sampled)

2) Fill out follow -up health questionnaire.

*** At 75 day period or (30 days after 90th dose) :

1) No supplement taken

2) Provide Hair sample as per Doctors Data collection procedures. (At home or mail in) at end of second 75 days. (Since hair only grows at avg. 1/3″ per month 30 more days must pass to show new toxic metal levels. Very important to follow directions– only hair 1/3″ from scalp to be sampled)

3) Final Health questionnaire.

Detailed original agreements, Doctors Data test reports, software and other original data is maintained in the offices of Science Formulas LLC . To protect patient confidentiality we cannot provide names of volunteers. However raw study data is available for review in excel spreadsheet format with written request to qualified researchers. We hereby certify all the attached data is based on actual final results provided by Doctors Data Inc.

Research Details:

Hair Samples : Hair samples were provided by each volunteer before any CHELOREX™  was consumed. Following completion of the 90-dose period, 30 days were added before the next hair sample was taken in order to allow for the slow growth rate of hair (1/3″ to ’12” per month) and to obtain a more accurate result of the chelator’s final leveling effect. Samples are taken from the back of head as close as possible to the scalp.

Testing Laboratory Services Discussion: Doctors Data Laboratory was selected as our preferred testing laboratory due to its established quality controls and longstanding reputation with other government agencies including The World Health Organization, the International Atomic Energy Agency, EPA, ATSDR, CDC, NIH and Justice Dept.. Blood & Hair Elemental profiles are measured with ICP-Mass Spectroscopy, and reported back with established comparative reference ranges along with actual results. Doctor’s Data’s reference ranges are established using the standardized protocol published by NCCLS. Reference ranges are determined using a comparative decision making process, utilizing Doctor’s Data’s hundreds of thousands of patient data and an American healthy population study. Doctor’s Data is licensed as a clinical laboratory by CLIA, New York, Florida, and Maryland. Doctor’s Data has scored consistently high on the CLIA mandated CAP, Le Centre de Toxicologie du Quebec, and New York Department of Health proficiency testing programs (PT), and performs interlaboratory comparisons with other labs that use ICP-MS such as Mayo Medical Labs.

Doctor’s Data has comparable results to other laboratories using ICP-MS as demonstrated by our successful participation in the comparison program for hair analysis by ICP-MS offered by Le Centre de Toxicologie du Quebec. A summary of Doctor’s Data proficiency testing program results is available upon request. In addition to PT, Doctor’s Data has extensive Quality Control processes that ensure precision and reliability which include calibration verification and monitoring standards; preparation blanks; laboratory controls and reference materials (low, medium, and high controls); spiked samples and duplicate analyses. Doctor’s Data uses a state-of-the-art laboratory dean room specially designed for trace element analysis, which includes metal-free walls, floors, and ceilings, ultra-pure water, and HEPA filtration systems.

Doctor’s Data uses a modified version of the standardized sample preparation method published by the International Atomic Energy Agency (IAEA/RL/50, Vienna). This method consists of cutting the hair into .3cm pieces and mixing to obtain a representative sample, washing the hair three times with Triton X-100 to remove external contamination, and rinsing with acetone and de-ionized water twice. The sample is then digested using trace metal free nitric acid and temperature controlled microwave digestion. This method has been demonstrated to remove external contamination yet retain volatile elements that can be cooked off using other methods such as open beaker digestion. For more information on Doctor’s Data’s method, see “Preparation of Hair for Measurement of Elements by Inductively Coupled-Mass Spectrometry (ICP-MS)”, Biological Trace Element Research, Vol. 62, 1998

Hair analysis lab info: To be performed by: DOCTOR’S DATA, INC ADDRESS: 3755 Illinois Avenue, St. Charles, IL 60174-2420 www.doctorsdata.com EMAIL: incluiries4tdoctorsdata.com TEL: 800.323.2784 FAX: 630.587.7860 LABORATORY DIRECTOR: James T. Hicks, MD, Ph.D., FCAP MEDICARE PROVIDER NO: 148453, CLIA ID NO: 14D0646470 TAX ID NO. (FEIN): 93-0941625